Why You Get IgA Nephropathy

2018-04-30 17:11

Why You Get IgA NephropathyIgA Nephropathy is so far the most common glomerulonephritis in the world. Do you know why you get it while some others do not? In this article, you will find out the answer.

Due to improper diet and environment pollution, harmful substances go into body and accumulate in the blood. When the body is not able to eliminate them, they can cause imbalance between inflammatory and anti-inflammatory ability of body so that body’s internal environment will go into inflammatory state, leading to micro-inflammation.

Under the simulation of repeated mucosal infections, such as pharyngitis, tonsillitis, enteritis and UTIs, immune system produces a large number of IgA 1 whose glycosylation is abnormal. Because human body can not remove these abnormal IgA 1, they combine with the corresponding specific antibodies to form immune complexes, which combine with specific receptions on renal mesangial cells and deposit on the glomerular mesangial area, further activating mesangial cells to an inflammatory state and causing the proliferation of mesangial cells and proliferation of mesangial matrix. And then cytokines affect glomerular endothelial cells and podocytes.

Endothelial cells activate autocrine and paracrine cytokines so as to disrupt endothelial cell intercellular connections, causing red blood cells to leak out into the urine and forming hematuria;

Podocytes activate autocrine and paracrine cytokines so as to destroy podocyte-associated proteins and the podocyte skeleton. This leads to impaired podocyte barriers and plasma proteins leaking out into the urine to form proteinuria.

In the beginning, you might have suffered from one kind of disease, but failed to pay enough attention, or the disease was not treated completely, which finally induce the occurrence of today's IgA nephropathy.

Why you get IgA Nephropathy? Now you get the answer. If you want to avoid further kidney damage, you should change your diet and try to reduce the accumulation of waste products in body. Here we recommend you to try Toxin-Removing Treatment, which can make internal environment good enough for kidney self-healing and other medication application. For more information on IgA Nephropathy treatment, please leave a message below or contact online doctor.

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